Helps facilitate early extubation1,2*,4†
Helps manage the intraoperative stress response1,2,5
Added characteristics of ULTIVA
- No difference in PK in obese patients (dose adjusted IBW)1
- Can be used in patients with renal or hepatic impairment1
- Well-established hemodynamic profile1
Cardiac case study––CABG
Obese 48-year-old male
5'10'', 95.7 kg (211 lb)
BMI 30.3 kg/m2
- Type 1 diabetes
- Renal insufficiency
Previous reaction to sulfa drugs
History of peripheral neuropathy, motion sickness, and claustrophobia
Medications: insulin, beta-blocker, ACE inhibitor
This case study is for illustrative and educational purposes only. The dosing regimen is specific to this case study and other regimens may vary depending on patient and procedure. Any use of this product is subject to the judgment of the practitioner in each case. Please consult the full Prescribing Information in the use of this product.
ULTIVA should be used with caution in obese patients. Clearance of remifentanil generally correlates with total body weight and may vary in morbidly obese patients due to variation in physiology and pharmacodynamics.
- ULTIVA [package insert]. Rockford, IL: Mylan Institutional LLC; 2016.
- Lison S, Schill M, Conzen P. Fast-track cardiac anesthesia: efficacy and safety of remifentanil versus sufentanil. J Cardiothorac Vasc Anesth. 2007;21(1):35-40. Supported by a grant from GlaxoSmithKline.
- Knapik M, Knapik P, Nadziakiewicz P, et al. Comparison of remifentanil or fentanyl administration during isoflurane anesthesia for coronary artery bypass surgery. Med Sci Monit. 2006;12(8):P133-P138.
- Howie MB, Cheng D, Newman MF, et al. A randomized double-blinded multicenter comparison of remifentanil versus fentanyl when combined with isoflurane/propofol for early extubation in coronary artery bypass graft surgery. Anesth Analg. 2001;92(5):1084-1093.
- Winterhalter M, Brandl K, Rahe-Meyer N, et al. Endocrine stress response and inflammatory activation during CABG surgery: a randomized trial comparing remifentanil infusion to intermittent fentanyl. Eur J Anaesthesiol. 2008;25(4):326-335.